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Lapatinib API Lapatinib Intermedicate cas 231277-92-2 

  產品分類 : 化學->藥品->醫藥

     
Lapatinib API Lapatinib Intermedicate cas 231277-92-2
       

  產品規格
 
  Country  CN

 

  產品描述
   
  <p class="MsoNormal">
Product Name: Lapatinib
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CAS NO.: 231277-92-2
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Molecular Formula: C29H26ClFN4O4S
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Molecular Weight: 581.0575432
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Description: White crystal or crystalline powder
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Package: 25KG/drums
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Chemical names, synonyms: Lapatinib(TINIBS), Lapatinib free base, GSK572016, GW 57201, Lapatinib(ditosylate salt), Lapatinib ditosylate
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Minimum purity: 99%
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<img src="http://i.bosscdn.com/product/21/0f/b2/6cb51f3de137d854f89efec8e5.gif" title="Lapatinib 231277-92-2" alt="Lapatinib 231277-92-2" />
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<p class="MsoNormal">
Lapatinib&nbsp;is&nbsp;a&nbsp;synthetic,&nbsp;orally-active&nbsp;quinazoline&nbsp;with&nbsp;potential&nbsp;antineoplastic&nbsp;activity.&nbsp;Lapatinib&nbsp;reversibly&nbsp;blocks&nbsp;phosphorylation&nbsp;of&nbsp;the&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;(EGFR),&nbsp;ErbB2,&nbsp;and&nbsp;the&nbsp;Erk-1&nbsp;and-2&nbsp;and&nbsp;AKT&nbsp;kinases;&nbsp;it&nbsp;also&nbsp;inhibits&nbsp;cyclin&nbsp;D&nbsp;protein&nbsp;levels&nbsp;in&nbsp;human&nbsp;tumor&nbsp;cell&nbsp;lines&nbsp;and&nbsp;xenografts.&nbsp;EGFR&nbsp;and&nbsp;ErbB2&nbsp;have&nbsp;been&nbsp;implicated&nbsp;in&nbsp;the&nbsp;growth&nbsp;of&nbsp;various&nbsp;tumor&nbsp;types.&nbsp;Check&nbsp;for&nbsp;active&nbsp;clinical&nbsp;trials&nbsp;or&nbsp;closed&nbsp;clinical&nbsp;trials&nbsp;using&nbsp;this&nbsp;agent.<br />
Lapatinib&nbsp;is&nbsp;an&nbsp;anti-cancer&nbsp;drug&nbsp;developed&nbsp;by&nbsp;GlaxoSmithKline&nbsp;(GSK)&nbsp;as&nbsp;a&nbsp;treatment&nbsp;for&nbsp;solid&nbsp;tumours&nbsp;such&nbsp;as&nbsp;breast&nbsp;and&nbsp;lung&nbsp;cancer.&nbsp;It&nbsp;was&nbsp;approved&nbsp;by&nbsp;the&nbsp;FDA&nbsp;on&nbsp;March&nbsp;13,&nbsp;2007,&nbsp;for&nbsp;use&nbsp;in&nbsp;patients&nbsp;with&nbsp;advanced&nbsp;metastatic&nbsp;breast&nbsp;cancer&nbsp;in&nbsp;conjunction&nbsp;with&nbsp;the&nbsp;chemotherapy&nbsp;drug&nbsp;Capecitabine.&nbsp;Lapatinib&nbsp;is&nbsp;human&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;type&nbsp;2&nbsp;(HER2/ERBB2)&nbsp;and&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;(HER1/EGFR/ERBB1)&nbsp;tyrosine&nbsp;kinases&nbsp;inhibitor.&nbsp;It&nbsp;binds&nbsp;to&nbsp;the&nbsp;intracellular&nbsp;phosphorylation&nbsp;domain&nbsp;to&nbsp;prevent&nbsp;receptor&nbsp;autophosphorylation&nbsp;upon&nbsp;ligand&nbsp;binding.
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</p>pharmachemm.com

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