產品資訊 - Apixaban API Apixaban intermediate cas 503612-47-3->pharmaceutical

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Apixaban API Apixaban intermediate cas 503612-47-3

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化學->藥品->醫藥

Apixaban API Apixaban intermediate cas 503612-47-3

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產品描述

Product name: apixaban 
Chemical names,synonyms: Eliquis,Apixaban API, BMS 562247-01,Apixaban, >=99%


CAS Number: 503612-47-3


Molecular Formula: C25H25N5O4  
Molecular Weight: 459.5 g.mol-1 
Package: foil bag, drum


Specifications: 
Minimum purity: 99.0 % 
Appearance: Off white powder 
Solubility: Sligthly soluble in Acetonitrile or Methanol , soluble in Dimethyl sulfoxide

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Apixaban acts by directly inhibiting, in a reversible manner, free and clot-bound factor Xa to inhibit coagulation. 
Apixaban is a new form of oral anticoagulant drug developed by Bristol Myers Squibb and Pfizer. It is a new form of oral Xa factor inhibitor, and its commercial name is Eliquis. Apixaban is used to treat adult patients undergoing elective hip or knee replacement surgery to prevent venous thromboembolism (VTE) 
Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).1 In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.2 Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.

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