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Trelagliptin CAS 865759-25-7 and SYR-472 

  產品分類 : 化學->藥品->醫藥

     
Trelagliptin CAS 865759-25-7 and SYR-472
       

  產品規格
 
  Country  CN

 

  產品描述
   
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Chemical Name: SYR-472
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SYR-472 succinate
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Trelagliptin Succinate (SYR-472)
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SYR 111472 succinate
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Trelagliptin succinat
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Molecular Formula: C22H26FN5O6
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Formula Weight: 475.4701432
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CAS No.: 1029877-94-8
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<img src="http://i.bosscdn.com/product/41/68/bb/d6cabbd2c989afbe88282c4984.gif" width="300" height="146" title="1029877-94-8" alt="1029877-94-8" />
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Chemical Name: Trelagliptin<br />
Molecular Formula: C18H20FN5O2<br />
Formula Weight: 357.3821032<br />
CAS No.: 865759-25-7<br />
MOL File: Mol file
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<img src="http://i.bosscdn.com/product/4b/78/92/e07d7850a3cca832005fd1dd63.gif" width="280" height="165" title="865759-25-7" alt="865759-25-7" />
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Trelagliptin&nbsp;(Zafatek)&nbsp;is&nbsp;an&nbsp;orally&nbsp;active&nbsp;dipeptidyl&nbsp;peptidase&nbsp;(DPP)-4&nbsp;inhibitor&nbsp;developed&nbsp;by&nbsp;Takeda&nbsp;and&nbsp;approved&nbsp;in&nbsp;Japan&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;type&nbsp;2&nbsp;diabetes&nbsp;mellitus&nbsp;(T2DM).&nbsp;Unlike&nbsp;other&nbsp;approved&nbsp;agents&nbsp;of&nbsp;its&nbsp;class,&nbsp;which&nbsp;are&nbsp;usually&nbsp;administered&nbsp;once&nbsp;daily,&nbsp;trelagliptin&nbsp;can&nbsp;be&nbsp;administered&nbsp;once&nbsp;weekly.&nbsp;Phase&nbsp;II&nbsp;development&nbsp;of&nbsp;trelagliptin&nbsp;was&nbsp;discontinued&nbsp;in&nbsp;the&nbsp;USA&nbsp;and&nbsp;EU,&nbsp;as&nbsp;Takeda&nbsp;considered&nbsp;that&nbsp;the&nbsp;costs&nbsp;associated&nbsp;with&nbsp;obtaining&nbsp;approval&nbsp;in&nbsp;these&nbsp;markets&nbsp;were&nbsp;prohibitive.&nbsp;This&nbsp;article&nbsp;summarizes&nbsp;the&nbsp;milestones&nbsp;in&nbsp;the&nbsp;development&nbsp;of&nbsp;trelagliptin&nbsp;leading&nbsp;to&nbsp;this&nbsp;first&nbsp;approval&nbsp;for&nbsp;T2DM.<br />
Shipping&nbsp;Condition:&nbsp;Shipped&nbsp;under&nbsp;ambient&nbsp;temperature&nbsp;as&nbsp;non-hazardous&nbsp;chemical.&nbsp;This&nbsp;product&nbsp;is&nbsp;stable&nbsp;enough&nbsp;for&nbsp;a&nbsp;few&nbsp;weeks&nbsp;during&nbsp;ordinary&nbsp;shipping&nbsp;and&nbsp;time&nbsp;spent&nbsp;in&nbsp;Customs.<br />
Storage&nbsp;Condition:&nbsp;Dry,&nbsp;dark&nbsp;and&nbsp;at&nbsp;0&nbsp;-&nbsp;4&nbsp;C&nbsp;for&nbsp;short&nbsp;term&nbsp;(days&nbsp;to&nbsp;weeks)&nbsp;or&nbsp;-20&nbsp;C&nbsp;for&nbsp;long&nbsp;term&nbsp;(months&nbsp;to&nbsp;years).<br />
Solubility:&nbsp;Soluble&nbsp;in&nbsp;DMSO,&nbsp;not&nbsp;in&nbsp;water<br />
Shelf&nbsp;Life:&nbsp;&gt;2&nbsp;years&nbsp;if&nbsp;stored&nbsp;properly<br />
Drug&nbsp;Formulation:&nbsp;This&nbsp;drug&nbsp;may&nbsp;be&nbsp;formulated&nbsp;in&nbsp;DMSO<br />
Stock&nbsp;Solution&nbsp;Storage:&nbsp;0&nbsp;-&nbsp;4&nbsp;C&nbsp;for&nbsp;short&nbsp;term&nbsp;(days&nbsp;to&nbsp;weeks),&nbsp;or&nbsp;-20&nbsp;C&nbsp;for&nbsp;long&nbsp;term&nbsp;(months<br />
relagliptin,&nbsp;also&nbsp;known&nbsp;as&nbsp;SYR-472,&nbsp;is&nbsp;a&nbsp;long&nbsp;acting&nbsp;dipeptidyl&nbsp;peptidase-4&nbsp;(DPP-4)&nbsp;inhibitor&nbsp;that&nbsp;is&nbsp;being&nbsp;developed&nbsp;by&nbsp;Takeda&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;type&nbsp;2&nbsp;diabetes&nbsp;(T2D).&nbsp;Once-weekly&nbsp;SYR-472&nbsp;treatment&nbsp;produced&nbsp;clinically&nbsp;and&nbsp;statistically&nbsp;significant&nbsp;improvements&nbsp;in&nbsp;glycaemic&nbsp;control&nbsp;in&nbsp;patients&nbsp;with&nbsp;type&nbsp;2&nbsp;diabetes.&nbsp;It&nbsp;was&nbsp;well&nbsp;tolerated&nbsp;and&nbsp;might&nbsp;be&nbsp;a&nbsp;new&nbsp;treatment&nbsp;option&nbsp;for&nbsp;patients&nbsp;with&nbsp;this&nbsp;disease.&nbsp;
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