產品資訊 - Apixaban intermeidate Cas 545445-44-1->active pharmaceutical ingredient

登入

加入會員

求助

JinanJianfengChemicalCo.,Ltd.

	Recommended Results

Apixaban intermeidate Cas 545445-44-1

產品分類 :

化學->活性醫療成份

產品規格

Country

產品描述

Chemical Name: 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one


Molecular Formula: C20H25N3O3 
Formula Weight: 355 
CAS No.: 545445-44-1


<img src="http://i.bosscdn.com/product/e0/26/d3/df60537fa57cd5a64a040e3808.gif" title="545445-44-1" alt="545445-44-1" /> 
An alternate approach to apixaban was described. The synthesis features a novel and cost-effective synthetic strategy to construct a key N-phenylvalerolactam intermediate 4 from 4-nitroaniline. In addition, the modifiedStroke Prophylaxis with Atrial Fibrillation 
Indicated to reduce risk of stroke and systemic embolism associated with nonvalvular atrial fibrillation 
 
5 mg PO BID 
 
Postoperative Prophylaxis of DVT/PE 
Indicated following hip or knee replacement surgery 
 
Initial: Give 2.5 mg PO 12-24 hr after surgery 
 
Duration of therapy (hip replacement): 2.5 mg PO BID for 35 days 
 
Duration of therapy (knee replacement): 2.5 mg PO BID for 12 days 
 
Renal impairment, including with ESRD on dialysis 
 
Deep Vein Thrombosis: No dose adjustment recommended; clinical efficacy and safety studies did not enroll patients with ESRD on dialysis or patients with a CrCl <15 mL/min; dosing recommendations are based on pharmacokinetic and pharmacodynamic (anti-FXa activity) data in study subjects with ESRD maintained on dialysis 
 synthetic route avoids the use of expensive reagents and significantly improves reaction yields. As demonstrated practically, apixaban was successfully synthesized in overall good yield (35%).


 
pharmachemm.com

其他類似產品