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suzhou nanomicro technology co., ltd.

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Silica Gel for Chromatography

產品分類 :

化學->其他->化學製品

產品規格

Model No:	UniSil 5-120

Country	CN
Payment Term	L/C,T/T

產品描述

UniSil® series of products meets the requirements of high performance liquid chromatography (HPLC) analysis in the laboratory and preparative separations in industry scale. Nanomicrotech is proud to be the leader of monodisperse chromatography silica gel with capability to produce in commercial scale.  UniSil® is a series of monodisperse spherical porous silica gels used for chromatography, produced by Suzhou Nanomicrotech Co. Ltd. from its unique patented technology that is developed in-house. The monodisperse spherical porous silica gel has distinct advantages, such as highly uniform particle size, perfect sphericity, outstanding mechanical strength, easy column packing, high column efficiency, good resolution, and low back pressure, UniSil® has already been widely used in analysis and separation of organic compounds, natural products, and large biomolecules. 

<img title="Silica Gel for Chromatography" alt="Silica Gel for Chromatography" src="http://i.bosscdn.com/product/f0/aa/fc/093f9e92b62b8bfb9871490dc4.png" /> 

Figure 1. SEM
micrographs of UniSil® monodisperse chromatography silica gel


Features and Benefits of UniSil® 

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Features

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Benefits

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  High uniformity of
particle size and perfect spherical shape

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   Easy column
packing, low back pressure, high efficiency and resolution

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  Optimal pore structure 

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   High loading capacity and high selectivity

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  Unique
surface bonding technology 

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   Good acid and
alkaline resistance, broad application pH range

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  High mechanical strength

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   Robust column packing and repacking, long
lifetime 

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  Large scale production 

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   Consistent product quality, short delivery
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High uniformity of particle
size and perfect spherical shape


UniSil® silica gel media are made to in
precise particle sizes with exceedingly high uniformity and perfect spherical
shape (Figures 2 and 3). When compared to other commercial chromatography
silica gels ( with broader particle size distribution), UniSil® has great
advantages of easy column packing, low back pressure, high column efficiency,
good resolution, stable column bed and reduced frit plugging.


 <img title="Chromatography UniSil" alt="Chromatography UniSil" src="http://i.bosscdn.com/product/93/d0/d6/f3b76141e4d1b6a9d48347f00d.png" />


Figure 2. Comparison of
UniSil® and well-known international brand chromatography silica gel


<img title="Silica Gel UniSil" alt="Silica Gel UniSil" src="http://i.bosscdn.com/product/9c/3c/84/318053ff9b85e9d4e24b363f23.png" />


 


Figure 3. Particle size distribution of UniSil® and well-known international
brand chromatography silica gel


<img title="Chromatography separation and purification" alt="Chromatography separation and purification" src="http://i.bosscdn.com/product/59/c3/79/6e6c3f831a780868d97c7a8843.png" />


 


Figure
4. Flow characteristics in chromatography media of different particle size
distributions


Optimal pore structure


The pore structure of silica gel has a great
influence on its mechanical strength, separation ability, and loading capacity.
Nanomicrotech not only controls precisely the particle size and size
distribution of the silica gel, but also optimizes pore structure forming,
desired surface area and pore volume. As the result, UniSil® silica gel has high loading capacity, strong
mechanical strength, and superior separation capability.


Unique surface bonding
technology


The selectivity and lifetime of a silica gel are
often determined by the bonding phase on its surface and end-capping. In
addition to the world leading technology of making silica gel, Nanomicrotech
has developed unique techniques of surface bonding and end-capping, which
enable UniSil® to be used with a broad pH range of application, good
separation selectivity, and peak symmetry. To meet customer needs, Nanomicrotech
also provides a variety of polar and non-polar bonded phase silica gel(C18,C8,C4,Phenyl,NH2,CN,Diol).


Figure 5 showed the separation of various
chemical substances by UniSil® 5-120 C18 reverse phase silica gel
media, including pyridine (alkaline compound). The high column efficiency and sharp
and symmetric peaks indicated the minimal residual silanol groups on the
surface (due to good end-capping).


<img title="Monodisperse microspheres" alt="Monodisperse microspheres" src="http://i.bosscdn.com/product/6e/64/6d/71ecd917ff27087637dcbdc7ae.png" />  


Figure 5. Chromatographic separation of various compounds by UniSil® 5-120 C18


 


Exceptional chemical
stability and resistance against acid and base


Nanomicrotech`s unique bonding and end-capping
techniques gave UniSil® exceptional resistance to acidic and
alkaline environment.  Figure 6 showed a
comparison of UniSil® 10-100 C8 with a leading commercial brand, in terms
of column efficiency (after alternating elution of columns with acidic and
alkaline solutions).  The results indicated
that the column packed with UniSil® maintains the column efficiency
much better than the other with commercial silica gels, suggesting a stronger
resistance against acid and base.


<img title="HPLC analysis" alt="HPLC analysis" src="http://i.bosscdn.com/product/77/9e/7b/77f9a2f13bade7c21408b46f84.png" />


 


Figure 6. Comparison of column efficiency,
between UniSil® 10-100 C8(green)and leading commercial brand(red), after treatment with acid
and base


 


  


Large scale production
capability and lot-to-lot consistency


State-of-the-art manufacturing facility at Nanomicrotech
allows a large scale production of UniSil® to meet the demands of industrial separation. Good
quality control system also assures the high quality and good lot-to-lot
consistency (as shown in Figure 7).


<img title="HPLC packing materials" alt="HPLC packing materials" src="http://i.bosscdn.com/product/4e/82/31/80fccbaddc1bba9f5c3be00a84.png" />


 


Figure 7. Lot-to-lot
consistency of UniSil® silica gel


 


Applications


Nanomicrotech has an in-house application development group with vast
experiences. This group provides customers with a lot of technical services,
from process development to technical transfer for production (industrial scale).
UniSil® silica gel media have been successfully applied to the
isolation and purification, including plant extracts(huperzine A, ginkgolide, panax notoginseng saponins), antibiotics(vancomycin, daptomycin, caspofungin, tiacumicin, Pneumocandin
B0, cyclosprin, erythromycin), polypeptides (tacrolimus, thymalfasin,
bivalirudin)and others(cod liver oil, bortezomib,
flurbiprofen axetil), etc.


List of Products


Nanomicrotech
supplies spherical silica gel media in the size range of 1.7 to 50 μm, with
different pore sizes, meeting the needs of high performance chromatographic
(HPLC) analysis in the lab and also preparative separation in industrial scale.

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Products

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Particle Size

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Pore Size

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Base Material

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Functional Groups

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μm

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Å

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UniSil® 

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1.7,3,5,10,20,30

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60,100,120,200,300,500

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Silica

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None,C18,C8,C4,NH2,Phenyl,CN,Diol

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NMSil 

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40~75,75~180

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100

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Silica

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None,C18,C8,C4,NH2,Phenyl,CN,Diol

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